Yes, it appears the server is running an unsupported .NET Framework. Their build numbers can be tricky, but this resolves .NET 4.0 based on what I could find. Which OS and OS build is this running on? We only support .NET 4.6.2 and newer in line with Microsoft's support policy of .NET Framework.
The HResult suggests the DLL could not be loaded, which might be due to the outdated runtime version. Another thing to verify is that the App Pool Identify has permissions to the directory where the profiler is unzipped. That could also prevent the DLL loading.