Failed to get node info error messages

We use ES 1.6.0. The system is composed of 35 indices, each with 5 shards and 1 replica.
We get many error messages on the TransportClient log file like this:

[INFO ] [2015-07-22 11:48:11.611] o.e.c.transport               : [Legacy] failed to get node info for [#transport#-1][om-inv][inet[om-inv/192.168.50.200:9300]], disconnecting...
org.elasticsearch.transport.ReceiveTimeoutTransportException: [][inet[om-inv/192.168.50.200:9300]][cluster:monitor/nodes/info] request_id [15675] timed out after [5009ms]
at org.elasticsearch.transport.TransportService$TimeoutHandler.run(TransportService.java:529)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1142)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:617)
at java.lang.Thread.run(Thread.java:745)

and like this one:

org.elasticsearch.client.transport.NoNodeAvailableException: None of the configured nodes are available: []
at org.elasticsearch.client.transport.TransportClientNodesService.ensureNodesAreAvailable(TransportClientNodesService.java:305)
at org.elasticsearch.client.transport.TransportClientNodesService.execute(TransportClientNodesService.java:200)
at org.elasticsearch.client.transport.support.InternalTransportClient.execute(InternalTransportClient.java:106)
at org.elasticsearch.client.support.AbstractClient.index(AbstractClient.java:102)
at org.elasticsearch.client.transport.TransportClient.index(TransportClient.java:340)
at org.elasticsearch.action.index.IndexRequestBuilder.doExecute(IndexRequestBuilder.java:266)
at org.elasticsearch.action.ActionRequestBuilder.execute(ActionRequestBuilder.java:91)
at org.elasticsearch.action.ActionRequestBuilder.execute(ActionRequestBuilder.java:65)

What is the significance of these and what can be done to fix them?

Could you share your modification to elasticsearch.yml? It might have something to do with your http, transport or gateway settings.

The only non-commented-out lines in our elasticsearch.yml are:

cluster.name: elasticsearch
node.name: om-inv
plugin.mandatory: head,analysis-icu,analysis-kuromoji,analysis-smartcn,analysis-stempel