Filter any documents containing any of several values in a number of fields

Is there any way to construct a filter that will filter out any documents
that match any values in an array from, say, 2 different fields?

Imagine a document that stores friendships/recommendations/etc, where the
document might store ids for each user as user_1 and user_2, and then other
information in whatever other fields you'd need. The important thing is
the user_1 and user_2 fields, but here's an idea of what the doc might look
like:

{
user_1: 12345,
user_2: 23456,
facebook_friends: true,
twitter_friends: false,
comments: "blahblahblahh"
}

I would like to execute a query that returns a set of documents but
excludes any friendships for a list of user ids. These excluded user_ids
might be listed as user_1 in some docs, but might be listed as user_2 in
others. I can easily construct a terms query for each field that will say
"exclude where user_1 is any of these values AND THEN exclude where user_2
is any of these values" but what I'd like to do is say "exclude where
either user_1 or user_2 are any of these values".

Right now I have to do this:

{
query: {
filtered: {
query: {
// whatever...
},
filter: {
bool: {
must_not: [
{
terms: {
user_1: [12345, 23456]
},
{
terms: {
user_2: [12345, 23456]
}
]
}
}
}
}
}

Some of these filters end up getting pretty large, and I'd like to be able
to avoid duplicating the array within the same query if I can. Something
like this would be awesome, but I can't figure out if there's any way to do
it:

{
query: {
filtered: {
query: {
// whatever...
},
filter: {
not: {
multi_match: {
terms: ["user_1", "user_2"],
values: [12345, 23456]
}
}
}
}
}
}

Thanks,
-Mike

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Bump

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