.NET Framework 4.6.1 (or newer) is supported via the Public API.
As to PCF support that will require further investigation.
.NET Framework 4.6.1 (or newer) is supported in the sense that you can use agent's public API to implement manual instrumentation. Automatic instrumentation for classic ASP.NET is planned for a future release. Regarding the ways to configure the agent in case of non .NET Core application - you can use environment variables and agent's public API. We have an issue in the backlog to support configuration via web.config for classic ASP.NET.
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