I feel that there is some issue with name resolving/connectivity/route tables.
Because it is giving "No route to host".
Try to check whether that IP(x.x.x.66) port 9300 is connecting.
As long as the Main cluster can respond to a query when the Remote cluster is down, the stack monitoring UI should load.
Alternatively if the .monitoring-* indices all stay on the Main cluster, you can set monitoring.ui.ccs.enabled: false (reference) which will make Stack Monitoring UI load using only indices from the Main cluster.
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